Science &


Keep in mind that setting up and completing clinical studies is not an inexpensive process. The fact that affron® has multiple studies across different health concerns and demographics (ages) should be another reassuring reason to make it part of your daily regimen.  Below you will find a brief summary of the topics and results along with a link to the published study for those who like more technical science. Adding to the amazing story behind affron®, the daily dose used in all studies (except for the bioavailability) us a small daily dose of just 28mg.  This is another great example of the power behind affron® being a superior saffron extract.

Improvement in Menopausal Symptoms

A study published in Journal of Menopausal Medicine evaluated the use of affron® in perimenopausal (early stages or around the time menopause begins) women and its impact on their menopausal complaints. The results showed an improvement in psychological symptoms and a strong tendency to improve hot flashes and sweating.  
Lopresti AL, et al. Journal of Menopausal Medicine. 2021;27:1-13

Improvements in Sleep Quality

A study published in Journal of Clinical Sleep Medicine measured in adults with self-reported sleep complaints for occasional sleeplessness. The results showed improved overall sleep quality, a reduction of awakenings after falling asleep and improved alertness upon waking up. Additionally, improvements were seen in as little as 7-days.
Lopresti AL, et al. J Clin Sleep Med. 2020

Sleep Enhancement in Adults

A study published in Japanese Pharmacology & Therapeutics evaluated the effect affron® had on sleep quality. The results showed a significant improvement in sleep quality associated with occasional sleeplessness. Daytime dysfunction from lack of sleep is a sign of abnormal sleep patterns, i.e., insomnia, a disease.
Nishide, A, et al. Japanese Pharmacology and Therapeutics. 2018 (8); 46:1407-1415

Affron® improved sleep quality at low dose

A new, randomized, double-blind, placebo-controlled study provided further confirmation of the sleep-enhancing effects of 28 days of affron® supplementation at 14 mg, 1 hour before bedtime, facilitating consumer’s adherence.
By the very first time, a single dose of affron® 1 hour before sleep revealed new possible mechanism of action influencing sleep hormones.
Lopresti AL, et al. Sleep Medicine 86. 2021;7-18

Improvements of Mood in Adults

A study published in Complementary Therapies in Medicine evaluated the impact of 28mg of affron® in adults. The results showed that affron® helped adults maintain a positive mood and alleviate occasional stress, frustration and tension.
Kell G., et al. Complement Ther Med. 2017 Aug; 33:58-64

Improvements in Mood in Teenagers (12-16 years of age)

A study published in Journal of Affective Disorders evaluated the effectiveness of affron® in children between the ages of 12 and 16. The results showed affron® has helped teenagers maintain a positive mood and alleviate occasional stress, frustration and tension from the child’s perspective. No adverse effects were reported by the children. 
Lopresti AL., et al. J Affect Disord. 2018 May; 232:349-357

Affron® has proven absorption into your body

It is well accepted that if you can’t absorb something, it won’t work. A study done with affron® and published in Evidence-Based Complementary and Alternative Medicine not only proved digestion but also absorption of the main active compounds found in affron®. Without digestion and absorption, a saffron product would offer little benefit. We can see from the study that affron® offers you the absorption you need. As if this wasn’t great enough, the study also showed that this process happened in just one hour after taking the affron® supplement. Affron® gets into your body fast to help you with your health needs quickly.
Almodovar P., et al. Evidence-Based Complementary and Alternative Medicine 2020

Mechanism of Action

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